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 U-47700 Fentanyl Analogues

U-47700

• Structure: U-47700 belongs to the class of synthetic opioids but does not share the structural backbone of fentanyl. Instead, it was initially developed as a potential painkiller.
• Potency: It is highly potent and has effects comparable to other powerful opioids, including euphoria, pain relief, and respiratory depression.
• Risks: U-47700 has been associated with numerous cases of intoxication and fatalities, largely due to its small therapeutic window and high risk of overdose.
• Legal Status: Due to its abuse potential and associated risks, U-47700 has been classified as a Schedule I controlled substance in several countries, meaning it has no accepted medical use.

Fentanyl Analogues

• Definition: Fentanyl analogs are chemically modified versions of fentanyl, a prescription opioid used for severe pain management.
• Potency: These analogs are often even more potent than fentanyl itself, with some being hundreds of times stronger than morphine.
• Risks: Due to their potency, even a small amount can cause respiratory failure and death, making them a significant contributor to the opioid overdose crisis.
• Illicit Use: Fentanyl analogs are frequently manufactured and distributed illegally, often mixed with other drugs or pressed into counterfeit pills, increasing the risk of unintentional overdoses.

Commonalities Between U-47700 and Fentanyl Analogues

• Both have been involved in opioid-related intoxications and fatalities.
• Both are characterized by their high potency and narrow margin of safety.
• Both are associated with the illegal drug market and are significant contributors to the opioid epidemic.

Chemical Properties of U-47700

• Molecular Formula: C₁₆H₂₂Cl₂N₂O
• Molecular Weight: 329.3 g/mol
• Chemical Structure:
  • Core Structure: Trans-3,4-dichloro-N-(2-(dimethylamino)cyclohexyl)-N-methylbenzamide.
  • Includes dichloro-substituents on the benzamide ring and a dimethylamino group.
• Pharmacology: Acts as a synthetic opioid with analgesic effects.

Fentanyl Analogues

• Molecular Formula: Varies depending on the analogue, but is based on the fentanyl core structure (C₂₂H₂₈N₂O).
• Chemical Modifications: Slight structural changes to fentanyl's backbone (e.g., substitutions on the piperidine ring or changes in the phenethyl group).
• Molecular Weight: Varies with the analog but typically in the range of 300-400 g/mol.
• Pharmacology: Extremely potent synthetic opioids, often 50–100 times stronger than morphine.

Physical Properties of U-47700

• Appearance: Often found as a white or light pink powder (hence the street name "Pinky").
• Melting Point: Approximately 218–222°C (based on analogous structures).
• Solubility: Soluble in organic solvents; limited solubility in water.

Fentanyl Analogues

• Appearance: Typically white to off-white powders, liquids, or transdermal patches, depending on the preparation.
• Melting Point: Varies depending on the specific analogue; typically ranges between 86°C and 106°C for fentanyl base.
• Solubility: High solubility in organic solvents; also soluble in water and lipids, contributing to high potency and rapid absorption.